While transgenderism is the Big Cultural thing at the moment, as with everything, there is a problem, arising from gender dysphoria itself. This condition means that individuals do not feel that they are in the correct body re gender. This problem is to be corrected medically and surgically, although it is somewhat odd that if everything is a social construction, it is necessary to use biological measures here rather than, well, sociology, which according to social constructionists, gives us the full answers to the nature of the universe, which is anyway, little more that a social idealist reflection in the mirror of sociology.
Still, that being said, the evidence indicates that, compared with cisgender men, there was an increased risk of overall mortality for transfeminine transgenders. And, compared with cisgender women, there was an increased risk of overall mortality for transmasculine adults. Sadly, these risks, as shown below, are represented as an increased risk for suicide and homicide, a most unfortunate state of affairs.