At a personal level the question will come up for the Covid vax from your doctor, who, being part of the sacred medical establishment, will be pushing for it. He/she will probably down-play issues of adverse effects. Like my doctor, whom I seldom see, as I despise the medical profession, who said that getting adverse effects was even more improbable than getting hit by a truck. He does not read this site or Dr Mercola, and he used to prescribe to me the drug Zantac, now removed. Still if one does not want to argue the science, the following article, based upon the precautionary principle gives a strategy of dealing with doc.
https://www.eurocanadian.ca/2021/08/to-vax-or-not-to-vax-that-difficult-discussion-with-your-doctor.html#more