Worse than Useless? By Brian Simpson

A recent study by a research team lead by leading virologist Dr David Ho, has concluded that the new mRNA vaxxes from Moderna and Pfizer produced fewer antibodies in subjects than did the previous shots used as a booster. Compared to people who had Omicron from an infection, there was less antibodies once more. These vaxxes were approved only with testing on a few mice, so maybe these vaxxes should be kept for mice only!

https://alexberenson.substack.com/p/the-new-omicron-specific-mrna-covid

“A new paper says people who got them actually generated FEWER antibodies to Omicron than those who got the older shots as a booster - and FAR fewer than people who had a natural Omicron infection

So much for the Omicron boosters.

Updated mRNA booster shots from Pfizer and Moderna - okayed for human use on the basis of data from a handful of mice - actually produce fewer useful antibodies against Omicron than a fourth jab with the original formulation.

Don’t take it from me. Take it from a paper released Monday from Dr. David Ho, one of the world’s top virologists.

Worse, newer Omicron variants evade both types of boosters with particular ease, the report found.

The report helps explain why Dr. Rochelle Walensky, the director of the Centers for Disease Control, was infected yet again last week with Sars-Cov-2 just a month after receiving her newest booster. Given that the original fourth dose appears to provide at most a few weeks of partial protection against Omicron infection, the booster dose may well offer NO protection at all against the new variants.

The report strongly suggests anyone who received mRNA shots should hope the next Sars-Cov-2 variants remain mild as the current Omicron variants, because those folks will have very little protection from future Sars-Cov-2 variants going forward.

In other words: immune imprinting and original mRNA vaccine antigenic sin are real, and they’re spectacular (spectacularly bad).

About the only good news in the study actually comes from vaccine failure. People who had three shots and then were infected with Omicron had markedly higher antibody levels than people who received either booster.”

https://www.biorxiv.org/content/10.1101/2022.10.22.513349v1.full.pdf

“The SARS-CoV-2 Omicron variant and its numerous sub-lineages have exhibited a striking  ability to evade humoral immune responses induced by prior vaccination or infection. The Food  and Drug Administration (FDA) has recently granted Emergency Use Authorizations (EUAs) to  new bivalent formulations of the original Moderna and Pfizer mRNA SARS-CoV-2 vaccines that  target both the ancestral strain as well as the Omicron BA.4/BA.5 variant. Despite their  widespread use as a vaccine boost, little is known about the antibody responses induced in  humans. Here, we collected sera from several clinical cohorts: individuals after three or four  doses of the original monovalent mRNA vaccines, individuals receiving the new bivalent  vaccines as a fourth dose, and individuals with BA.4/BA.5 breakthrough infection following  mRNA vaccination. Using pseudovirus neutralization assays, these sera were tested for  neutralization against an ancestral SARS-CoV-2 strain, several Omicron sub-lineages, and  several related sarbecoviruses. At ~3-5 weeks post booster shot, individuals who received a  fourth vaccine dose with a bivalent mRNA vaccine targeting BA.4/BA.5 had similar neutralizing  antibody titers as those receiving a fourth monovalent mRNA vaccine against all SARS-CoV-2  variants tested, including BA.4/BA.5. Those who received a fourth monovalent vaccine dose had  a slightly higher neutralizing antibody titers than those who received the bivalent vaccine against  three related sarbecoviruses: SARS-CoV, GD-Pangolin, and WIV1. When given as a fourth  dose, a bivalent mRNA vaccine targeting Omicron BA.4/BA.5 and an ancestral SARS-CoV-2  strain did not induce superior neutralizing antibody responses in humans, at the time period  tested, compared to the original monovalent vaccine formulation.”