The Triple Vaxxed for Covid Recover More Slowly from Covid and are Contagious for Longer than the Unvaxxed By Brian Simpson

With the PM Albo pushing now for four jabs of the Covid vax goo, it is ironic that peer reviewed scientific studies, such as one recently published in the leading medical journal, The New England Journal of Medicine, are showing limitations of the vax, within a mainstream paradigm. Thus, a study based at the Mass General Brigham, Boston, showed that triple vaxxed people recovered slower than those who were unvaccinated, and the triple vaxxed were contagious for longer than the unvaccinated. Those who received a booster shot were five times more likely  to be contagious at ten days after infection than the unvaccinated.

https://www.israelnationalnews.com/news/356245

“A new study published in the New England Journal of Medicine (NEJM) has demonstrated that people who are triple-vaccinated (boosted) against COVID recover significantly more slowly from COVID infection and remain contagious for longer than people who are not vaccinated at all.

The study did not deal with the severity of illness with or without a vaccine.

Researchers swabbed infected people and cultured the swabs, repeating the process for over two weeks until viral replication was not observed.

At five days post-infection, less than 25 percent of unvaccinated people were still contagious, whereas around 70 percent of boosted people were still carrying viable virus particles. For those partially vaccinated, around 50 percent were still contagious at this point.

Even more strikingly, at ten days post-infection, one-third of boosted people (31 percent) were found to still be carrying live, culturable virus. By contrast, just six percent of unvaccinated people were still contagious at day 10.

In other words, people who have received a booster shot are five times more likely still to be contagious at ten days post-infection than are unvaccinated people.

The findings go a long way to explaining why Paxlovid, Pfizer's anti-viral medication, is often not effective for people who have been vaccinated against COVID, with many experiencing a recurrence of symptoms along with a positive COVID test after completing the five-day regimen (as recently occurred with quadruple-vaccinated Dr. Anthony Fauci). This phenomenon is known as COVID rebound.

Meanwhile, Israeli Health Ministry data shows that in the older population (those over the age of 60), having submitted to more COVID shots often correlates to a greater likelihood of becoming infected with COVID.”

https://www.nejm.org/doi/full/10.1056/NEJMc2202092

“The B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a shorter incubation period and a higher transmission rate than previous variants.^1,2 Recently, the Centers for Disease Control and Prevention recommended shortening the strict isolation period for infected persons in non–health care settings from 10 days to 5 days after symptom onset or after the initial positive test, followed by 5 days of masking.³ However, the viral decay kinetics of the omicron variant and the duration of shedding of culturable virus have not been well characterized.

We used longitudinal sampling of nasal swabs for determination of viral load, sequencing, and viral culture in outpatients with newly diagnosed coronavirus disease 2019 (Covid-19).⁴ From July 2021 through January 2022, we enrolled 66 participants, including 32 with samples that were sequenced and identified as the B.1.617.2 (delta) variant and 34 with samples that were sequenced and identified as the omicron subvariant BA.1, inclusive of sublineages. Participants who received Covid-19–specific therapies were excluded; all but 1 participant had symptomatic infection. This study was approved by the institutional review board and the institutional biosafety committee at Mass General Brigham, and informed consent was obtained from all the participants.

The characteristics of the participants were similar in the two variant groups except that more participants with omicron infection had received a booster vaccine than had those with delta infection (35% vs. 3%) (Tables S1 and S2 in the Supplementary Appendix, available with the full text of this letter at NEJM.org). In an analysis in which a Cox proportional-hazards model that adjusted for age, sex, and vaccination status was used, the number of days from an initial positive polymerase-chain-reaction (PCR) assay to a negative PCR assay (adjusted hazard ratio, 0.61; 95% confidence interval [CI], 0.33 to 1.15) and the number of days from an initial positive PCR assay to culture conversion (adjusted hazard ratio, 0.77; 95% CI, 0.44 to 1.37) were similar in the two variant groups (Figure 1A through 1C and S1 through S3, and Tables S3 through S5). The median time from the initial positive PCR assay to culture conversion was 4 days (interquartile range, 3 to 5) in the delta group and 5 days (interquartile range, 3 to 9) in the omicron group; the median time from symptom onset or the initial positive PCR assay, whichever was earlier, to culture conversion was 6 days (interquartile range, 4 to 7) and 8 days (interquartile range, 5 to 10), respectively. There were no appreciable between-group differences in the time to PCR conversion or culture conversion according to vaccination status, although the sample size was quite small, which led to imprecision in the estimates (Figure 1D and 1E).

In this longitudinal cohort of participants, most of whom had symptomatic, nonsevere Covid-19 infection, the viral decay kinetics were similar with omicron infection and delta infection. Although vaccination has been shown to reduce the incidence of infection and the severity of disease, we did not find large differences in the median duration of viral shedding among participants who were unvaccinated, those who were vaccinated but not boosted, and those who were vaccinated and boosted.

Our results should be interpreted within the context of a small sample size, which limits precision, and the possibility of residual confounding in comparisons according to variant, vaccination status, and the time period of infection. Although culture positivity has been proposed as a possible proxy for infectiousness,⁵ additional studies are needed to correlate viral-culture positivity with confirmed transmission in order to inform isolation periods. Our data suggest that some persons who are infected with the omicron and delta SARS-CoV-2 variants shed culturable virus more than 5 days after symptom onset or an initial positive test.”

https://www.medrxiv.org/content/10.1101/2022.06.28.22276926v1.full.pdf