Natural Protection from Covid: Serum anti-SARS-CoV-2 IgA By Brian Simpson

Researchers from the University of Gothenburg, at  the University’s Sahlgrenska Academy investigated 156 employees from five primary care health facilities who were recruited during April and May 2020, who had not been vaccinated. It was found that IgA (immunoglobulin A) was in the respiratory tracts of several of the personnel who didn't catch Covid-19. This is part of the first-line defences of the immune system, found naturally in mucous membrane secretions in the airways and gastrointestinal tract. So, yes, the mainstream scientific establishment are finding that natural immunity does exist.

https://onlinelibrary.wiley.com/doi/10.1002/eji.202149655

“The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19,”

Viktoria Hennings  et al., https://doi.org/10.1002/eji.202149655

 

“Abstract

The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T-cell proliferation and cytokine secretion, demographic and clinical data, PCR-verified infection, and self-reported symptoms were monitored. The multivariate method OPLS-DA was used to identify immune response patterns coupled to protection from Covid-19. Contracting Covid-19 was associated with SARS-CoV-2-specific neutralizing serum IgG, T cell, IFN-γ, and granzyme B responses to SARS-CoV-2, self-reported typical Covid-19 symptoms, male sex, higher BMI, and hypertension. Not contracting Covid-19 was associated with female sex, IgA-dominated, or no antibody responses to SARS-CoV-2, airborne allergy, and smoking. The IgG-responders had SARS-CoV-2-specific T-cell responses including a cytotoxic CD4+ T-cell population expressing CD25, CD38, CD69, CD194, CD279, CTLA-4, and granzyme B. IgA-responders with no IgG response to SARS-CoV-2 constituted 10% of the study population. The IgA responses were partially neutralizing and only seen in individuals who did not succumb to Covid-19. To conclude, serum IgG-dominated responses correlated with T-cell responses to SARS-CoV-2 and PCR-confirmed Covid-19, whereas IgA-dominated responses correlated with not contracting the infection.”

 

 

 

 

 

 

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Thursday, 28 March 2024

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