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The Question of Chloroquine By Mrs Vera West

     President Trump thinks that the drug chloroquine may be a game changer in the coronavirus pandemic. But the false news media said that Trump was responsible for a man who died from self-medication of the alleged drug, when in fact the man died because he ingested fish tank cleaner, a fair bit of difference, not that the mainstream liars care that much, as long as the mud sticks for a moment:
  https://www.thegatewaypundit.com/2020/03/fake-news-hacks-claim-man-died-after-ingesting-chloroquine-because-of-trump-leaves-out-the-fact-he-actually-drank-fish-tank-cleaner/

“Late last week President Donald Trump announced a new medical treatment that includes malaria drug chloroquine and Z-pac cocktail to battle the coronavirus. There are three international studies that show the combination is very effective in treating the coronavirus and also acts as a prophylactic. We reported on the success of Chloroquine earlier today and this week. The propagandists in the media however are desperate to make President Trump look like a murdering liar so they spread one of the biggest hoaxes yet in the Coronavirus news cycle. On Monday it was reported that a 68-year-old man died after ingesting chloroquine. Only he didn’t ingest chloroquine — he drank fish tank cleaner and poisoned himself to death. But the media ran with the lie anyway, because orange man bad.”

     In fact, it is not too hard to find a fair bit of evidence for Trump’s position, but of course, full medical evaluation will be needed so everybody needs to get a wriggle on. India certainly seems to agree with Trump:
  https://www.businesstoday.in/current/economy-politics/coronavirus-outbreak-icmr-recommends-use-hydroxy-chloroquine-critical-covid-19-cases/story/399005.html

“The National Task Force for COVID-19, constituted by Indian Council of Medical Research (ICMR), on Monday recommended the use of hydroxy-chloroquine for preventive treatment of healthcare workers and individuals in close contact of coronavirus patients. The task force has recommended the use of hydroxy-chloroquine for prophylaxis of SARS-CoV-2 infection for selected individuals, such as asymptomatic healthcare workers involved in the care of suspected or confirmed cases of COVID-19. The drug may be also used in case of asymptomatic household contacts of confirmed COVID-19 patients.

"Hydroxy-chloroquine is found to be effective against coronavirus in laboratory studies and in-vivo studies. Its use in prophylaxis is derived from available evidence of benefit as treatment and supported by pre-clinical data," ICMR said in its latest report on Monday.
Commenting on the development, ICMR Director-General Balram Bhargava said, "Hydroxy-chloroquine is recommended only for a healthcare worker who is treating a Covid 19 patient. Secondly, it's recommended only for persons staying and caring for a household positive patient. They can take that only for prophylaxis, only for prevention."
https://www.expresshealthcare.in/news/advisory-on-use-of-hydroxy-chloroquine-as-prophylaxis-for-sars-cov-2-infection/417793/
“Protocol recommended by National Task force has been approved by Drug Controller General of India for restricted use in emergency situations
The National Task force for COVID-19 constituted by Indian Council of Medical Research recommends the use of hydroxy- chloroquine for prophylaxis of SARS-CoV-2 infection for high risk population.
The advisory provides for placing the following high risk population under chemoprophylaxis with hydroxy chloroquine:
•    Asymptomatic healthcare workers involved in the care of suspected or confirmed cases of COVID-19
•    Asymptomatic household contacts of laboratory confirmed cases
The protocol recommended by the National Task force has been approved by the Drug Controller General of India for restricted use in emergency situations.
While following the above recommendations, States should take note of the following:
The placing of healthcare workers under chemoprophylaxis should not instill a sense of false security. They should follow all prescribed public health measures such as frequent washing of hands, respiratory etiquettes, keeping a distance of minimum one metre and use of personal protective equipment (wherever applicable).
They should self-monitor their health and report to health authorities immediately in the event of them becoming symptomatic.
The high risk contacts of a positive case placed under chemo prophylaxis, should remain in home quarantine while on prophylactic therapy.
As recommended by the said Task Force, the drug should only be given on the prescription of a registered medical practitioner. The contraindications mentioned in the recommendations should strictly be followed.
Apart from the symptoms of COVID-19 (fever, cough, breathing difficulty), if the person on chemo¬prophylaxis develops any other symptoms, he should immediately seek medical treatment of the medical practitioner who has prescribed the chemoprophylaxis.
It is reiterated that the intake of the above medicine should not in still sense of false security.”

     Then we have the case of the brilliant Hasidic Jewish doctor, Vladimir Zelenko, who has been using hydroxychloroquine in treatments of his orthodox patients, none of whom have died:
  https://forward.com/news/national/442285/coronavirus-hydroxychloroquine-trump-doctor/
  https://www.thegatewaypundit.com/2020/03/stunning-ny-doctor-vladimir-zelenko-finds-100-success-rate-in-350-patients-using-hydroxychloroquine-with-z-paks-video/

“Over the weekend Dr. Vladimir Zelenko from New York state announced he has found a treatment against the coronavirus with a 100% success rate on 350 patients. Dr. Zelenko joined Sean Hannity earlier today on his radio program to discuss the results from his test. The New York doctor also posted a video explaining his success with hydroxychloroquine and Zinc .  His treatment resulted in the shortness of breath issue being resolved in 4 to 6 hours.  Dr. Zelenko in his study had zero deaths, zero hospitalizations and zero intubations! Later on Monday evening Sean Hannity invited two more medical experts on to discuss Dr. Zelenko’s coronavirus results. The two doctors were cautiously optimistic.”

  https://www.breitbart.com/politics/2020/03/19/chloroquine-known-as-effective-against-coronavirus-since-2005/

“The world economy is collapsing because of the terror and mounting death toll caused by the Coronavirus pandemic. But the anti-malarial drug chloroquine is effective both as a prophylactic and treatment for the virus – and the medical establishment has known about this since at least the SARS coronavirus outbreak in 2005. What the hell is going on? Yesterday, I reported the existence of three studies, all claiming that chloroquine phosphate had proved effective in treating the COVID-19. This has since been confirmed by a more recent open-label non-randomised clinical trial in France by Didier Raoult M.D/Ph.D et al, completed just days ago. The sample was small but the results were convincing. As the summary reports: 100% of patients that received a combination of HCQ and Azithromycin tested negative and were virologically cured within 6 days of treatment. In addition, recent guidelines from South Korea and China report that hydroxychloroquine and chloroquine are effective antiviral therapeutic treatments for novel coronavirus. But the story gets more extraordinary still. It turns out that the Centers for Disease Control and Prevention (CDC) has known since at least 2005 that chloroquine is effective against coronaviruses. In 2005, Martin J Vincent et al published a study in Virology Journal titled ‘Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.’

Here are its findings:
Background
Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.
Results
We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.
Conclusion
Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.
It ought to be no surprise that chloroquine is effective against both SARS and COVID-19. After all, they are both coronaviruses and COVID-19 has often been described in medical and research sources as SARS-2.
Chloroquine works by enabling the body’s cells better to absorb zinc, which is key in preventing viral RNA transcription – and disrupting the often fatal cytokine storm.
As at least one person has noticed, the implications of this are enormous. If the medical establishment – including CDC – has been aware of the efficacy of chloroquine in treating coronavirus for at least 14 years, why has it not been mass produced and made available sooner?”

  https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69
  https://www.globalresearch.ca/video-ny-doctor-vladimir-zelenko-finds-100-success-rate-350-patients-using-hydroxychloroquine-zinc/5707381

     If hydroxychloroquine does have the effects as described above, then the question needs to be asked: if this drug was known to be a goer since 2005, why has the medical establishment dragged its feet in evaluation? On the other hand it could be that the studies cited are indeed limited, or there is some flaw. Who know? But, we should know! This is the time for biomedical researchers to cut sleep and stay in the labs until they get results.

 

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Thursday, 09 July 2020
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