If You Get Reflux, This is a Real Worry By Mrs Vera West
Many of us who suffer from reflux, a pain that feels like a heart attack seek relief from this condition by Proton Pump Inhibitors. But there could be a problem from long term use, with deleterious effects upon the kidneys:
This is so important that I will go straight to the primary source, in the British Medical Journal:
Objective To estimate all cause mortality and cause specific mortality among patients taking proton pump inhibitors (PPIs).
Design Longitudinal observational cohort study.
Setting US Department of Veterans Affairs.
Participants New users of PPIs (n=157 625) or H2 blockers (n=56 842).
Main outcome measures All cause mortality and cause specific mortality associated with taking PPIs (values reported as number of attributable deaths per 1000 patients taking PPIs).
Results There were 45.20 excess deaths (95% confidence interval 28.20 to 61.40) per 1000 patients taking PPIs. Circulatory system diseases (number of attributable deaths per 1000 patients taking PPIs 17.47, 95% confidence interval 5.47 to 28.80), neoplasms (12.94, 1.24 to 24.28), infectious and parasitic diseases (4.20, 1.57 to 7.02), and genitourinary system diseases (6.25, 3.22 to 9.24) were associated with taking PPIs. There was a graded relation between cumulative duration of PPI exposure and the risk of all cause mortality and death due to circulatory system diseases, neoplasms, and genitourinary system diseases. Analyses of subcauses of death suggested that taking PPIs was associated with an excess mortality due to cardiovascular disease (15.48, 5.02 to 25.19) and chronic kidney disease (4.19, 1.56 to 6.58). Among patients without documented indication for acid suppression drugs (n=116 377), taking PPIs was associated with an excess mortality due to cardiovascular disease (22.91, 11.89 to 33.57), chronic kidney disease (4.74, 1.53 to 8.05), and upper gastrointestinal cancer (3.12, 0.91 to 5.44). Formal interaction analyses suggested that the risk of death due to these subcauses was not modified by a history of cardiovascular disease, chronic kidney disease, or upper gastrointestinal cancer. Taking PPIs was not associated with an excess burden of transportation related mortality and death due to peptic ulcer disease (as negative outcome controls).
Conclusions Taking PPIs is associated with a small excess of cause specific mortality including death due to cardiovascular disease, chronic kidney disease, and upper gastrointestinal cancer. The burden was also observed in patients without an indication for PPI use. Heightened vigilance in the use of PPI may be warranted.
Here is a summary added at the end:
What is already known on this topic:
• Taking proton pump inhibitors (PPIs) is associated with several serious adverse events and with an increased risk of all cause mortality
What this study adds
• Taking PPIs is associated with an excess of mortality from cardiovascular disease and chronic kidney disease
• Patients without a documented indication for acid suppression drugs have an excess mortality due to cardiovascular disease, chronic kidney disease, and upper gastrointestinal cancer
• Previous history of cardiovascular disease, chronic kidney disease, and upper gastrointestinal cancer do not modify the relation between PPI use and the risk of death due to cardiovascular disease, chronic kidney disease, and upper gastrointestinal cancer, respectively
No health advice is offered here since I am not a qualified medical professional. But, if you are on Proton Pump Inhibitors, it may be wise to print off the British Medical Journal article and take it to your doctor and get an opinion. He/she may need to take it home and read it, because our hard-working doctors are always open to updating their knowledge in the light of the latest peer reviewed research. Why, doc has probably already read up on this.