Hybrid Immunity Trumps the Vax By Brian Simpson

Slowly the truth is leaking out, with scientific research from UConn Health investigators, now examining core aspects of the Covid narrative. One recent article, published in the journal, Vaccines, compared Covid vax immunity with so-called hybrid immunity. It was found that healthcare workers who were vaccinated and experienced symptomatic Covid-19, gained more robust immunity than those who did not experience a breakthrough symptomatic infection. It was concluded that the current mRNA Covid vaxxes does not produce a robust vaccine. That conclusion flies in the face of the narrative that was produced in the last few years. It is a small indication that the mainstream Covid narrative, chipped away for years, is starting to break down.

https://www.mdpi.com/2076-393X/11/2/358

https://today.uconn.edu/2023/03/the-stronger-the-side-effects-the-longer-lasting-the-vax/#

https://www.trialsitenews.com/a/uconn-health-worker-study-mrna-vaccine-effectiveness-waneshybrid-immunity-superior-90092a05

“Yet more evidence surfaces that so-called hybrid immunity trumped vaccine-induced immunity, according to recent study findings published in the journal Vaccines. Led by UConn Health investigators, the recent study reveals that healthcare workers who were vaccinated yet went on to experience symptomatic COVID-19 gained more robust immunity than those who didn’t experience a breakthrough symptomatic infection. The study just adds to the evidence that current mRNA COVID-19 vaccine durability isn’t sufficient for a robust, sustainable, long-term vaccine product. 

While healthcare workers such as nurses, doctors, and other staff experienced high rates of SARS-CoV-2 exposure, especially early on during the pandemic, University of Connecticut’s UConn Today reports that this cohort was an ideal group to study the effects of the COVID-19 vaccines that were available by spring 2021.

As reported by Kim Krieger at the university’s communications department, the UConn study team recruited 296 of their colleagues to participate in a vaccine study that began that spring, including 46 who had already had COVID.

Study subjects were inoculated with either the Pfizer-BioNTech (BNT162b2) or the Moderna (mRNA-1273) mRNA vaccines, whichever was available at the time. (Originally the study included healthcare workers vaccinated with Johnson & Johnson’s product, but not enough participants ended up receiving that vaccine to make the results statistically significant.)

The UConn health workers in the study had their blood tested for neutralizing antibodies at two months post-vaccination, then at five months, and again at nine months.

Summary of the Effects

UConn reports on the science behind the neutralizing antibodies--they specifically attack the parts of the virus important for infection. Other antibodies might react to parts of the virus but be ineffective at stopping it from infecting other cells. Not all antibody tests look specifically for neutralizing antibodies, and that specificity is one of this study’s strengths, says UConn School of Medicine chief of infectious diseases Kevin Dieckhaus, one of the authors.

Waning Effectiveness of mRNA Vaccines

As reported by Dieckhaus and colleagues, the data becomes clear--the mRNA vaccines elicit a strong neutralizing antibody response in the first few months from people who have never been infected with COVID before. But the level of neutralizing antibodies drops off steeply by nine months.

Hybrid Coverage Stronger

In people who have already been infected with COVID, the response is stronger: the neutralizing antibody response is higher initially and doesn’t drop off as steeply over time. And in both groups, getting a fever, aches, or a sore arm after vaccination predicted a stronger, longer lasting neutralizing antibody response.

The data confirms what earlier studies had reported. In middle aged people, the antibody response from the vaccines is relatively strong but short lived.

Principal Investigator POV

Dieckhaus went on the record regarding their findings: “Prior infection with COVID meant you were more likely to have a sustained immune response. It definitely sets your immune system to respond in a more vigorous way to the vaccination.”

What’s Next?

The researchers are continuing the study and currently tracking antibody levels in participants who received boosters, as well as whether they have contracted COVID since being vaccinated. They hope to help answer other questions, such as whether the antibody response to boosters behaves similarly over time to the initial shots, and why some people get infected with COVID repeatedly while others don’t.”

 

 

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Monday, 22 April 2024

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