Geert Vanden Bossche, a virologist, and Covid critic, responds to the question, of what would be your prediction for those who are both unvaccinated against Covid-19 and never previously infected? It seems that the unvaccinated will face the new variants and have their immune system fight against these new bugs, but not having had the dreaded vaxxes, there will not be immune system compromise, of VAIDS, Vaccine Immunodeficiency Syndrome, or ADE, antibody dependent enhancement, so, as with Covid 1.0, they will generally do fine.

https://www.voiceforscienceandsolidarity.org/scientific-blog/q-a-18-what-would-be-your-prediction-for-those-who-are-both-unvaccinated-against-covid-19-and-never-previously-infected

Extended question:

What would be your prediction for those who are both unvaccinated against COVID-19 and never previously infected? Let's say those of working age(20 - 55) in fairly good health.
Should they be worried about Avian Flu and Monkeypox, since they have not experienced an infection by SARS-CoV-2?
Are they at risk for serious illness from these more infectious (and future more virulent) SARS-CoV-2 mutants?

Answer:

It would be quite unbelievable that they didn’t get exposed to SC-2 given the high infectiousness of previously and currently circulating variants. Ideally, they should have their Abs tested (anti-S would be sufficient since they’re not vaccinated). They can also have their Abs tested against Flu. If all this is negative (which would point to poor activation of natural immunity), they can just take one shot of a live attenuated measles or mumps or rubella or varicella vaccine (or all together in one shot) to boost their innate immune response. (However, they should only do so if they got MMR(V)-vaccinated in the past. The better their innate immune status, the lower the likelihood they are going to catch severe disease from these viruses. But anyhow, for a person in good health, it is highly unlikely to develop severe disease from Monkeypox (as it is - for now(!) - not highly infectious) or from Avian Flu as they must at least have had contact with Flu viruses in the past and hence, have some ‘Flu-trained’ innate immunity.)

Unvaccinated can now largely forget about contracting severe C-19 disease as the next big mutation will most likely make the unvaccinated resistant to the virus. However, if they have not yet been infected at all by any of these highly infectious variants, they could still contract C-19 disease (before that new variant emerges) and become seriously ill (but not ‘severely ill’ as long as they are in good health with no comorbidities and predisposing factors).”