Against the Covid Mandates: Predominance of Antibody-Resistant SARS-CoV-2 Variants in Vaccine Breakthrough Cases By Brian Simpson

A recent scientific paper, yet to be peer-reviewed, has examined the association between vaccine breakthrough cases and SARS-CoV-2) variants, base upon a study of the San Francisco Bay area. As the paper says: “Fully vaccinated were more likely than unvaccinated persons to be infected by variants carrying mutations associated with decreased antibody neutralization … Taken together, our results suggest that vaccine breakthrough infections are overrepresented by circulating antibody-resistant SARS-CoV-2 variants, and that symptomatic breakthrough infections may potentially transmit COVID-19 as efficiently as unvaccinated infections, regardless of the infecting lineage.” In other words, the Covid vaccinated may spread Covid as efficiently as the unvaccinated. If I understand this, and this is my interpretation only, it shows that the Covid mandates, such as in totalitarian Victoria, are doomed to fail. The manic drive for mass vaccination may well create an evolutionary force to produce mutant variants of SARS-CoV-2.

https://www.medrxiv.org/content/10.1101/2021.08.19.21262139v2?utm_source=gnaa

Predominance of antibody-resistant SARS-CoV-2 variants in vaccine breakthrough cases from the San Francisco Bay Area, California, By Venice Servellita, Alicia Sotomayor-Gonzalez, Amelia S. Gliwa, Erika Torres, Noah Brazer, Alicia Zhou, Katherine T. Hernandez, Maddie Sankaran, Baolin Wang, Daniel Wong, Candace Wang, Yueyuan Zhang, Kevin R Reyes, Dustin Glasner, Xianding Deng, Jessica Streithorst, Steve Miller, Edwin Frias, Mary Rodgers, Gavin Cloherty, John Hackett Jr., Susan Philip, Scott Topper, Darpun Sachdev,  View ORCID ProfileCharles Y. Chiu

doi: https://doi.org/10.1101/2021.08.19.21262139

“Abstract

Associations between vaccine breakthrough cases and infection by SARS coronavirus 2 (SARS-CoV-2) variants have remained largely unexplored. Here we analyzed SARS-CoV-2 whole-genome sequences and viral loads from 1,373 persons with COVID-19 from the San Francisco Bay Area from February 1 to June 30, 2021, of which 125 (9.1%) were vaccine breakthrough infections. Fully vaccinated were more likely than unvaccinated persons to be infected by variants carrying mutations associated with decreased antibody neutralization (L452R, L452Q, E484K, and/or F490S) (78% versus 48%, p = 1.96e-08), but not by those associated with increased infectivity only (N501Y) (85% versus 77%, p = 0.092). Differences in viral loads were non-significant between unvaccinated and fully vaccinated persons overall (p = 0.99) and according to lineage (p = 0.09 – 0.78). Viral loads were significantly higher in symptomatic as compared to asymptomatic vaccine breakthrough cases (p < 0.0001), and symptomatic vaccine breakthrough infections had similar viral loads to unvaccinated infections (p = 0.64). In 5 cases with available longitudinal samples for serologic analyses, vaccine breakthrough infections were found to be associated with low or undetectable neutralizing antibody levels attributable to immunocompromised state or infection by an antibody-resistant lineage. Taken together, our results suggest that vaccine breakthrough infecions are overrepresnted by circulating antibody-resistant SARS-CoV-2 variants, and that symptomatic breakthrough infections may potentially transmit COVID-19 as efficiently as unvaccinated infections, regardless of the infecting lineage.”