The rollout of mRNA-based COVID-19 vaccines, such as Pfizer's Comirnaty (BNT162b2) and Moderna's Spikevax (mRNA-1273), was hailed as a triumph of modern science, offering a rapid response to the SARS-CoV-2 pandemic. These vaccines work by instructing human cells to produce the SARS-CoV-2 spike protein, which triggers an immune response to protect against severe disease. However, emerging research has raised serious concerns about their safety, particularly regarding their potential to cause cardiac harm. A groundbreaking study by Dr. Rolf Schreckenberg and his team from Justus-Liebig University Gießen and Hannover Medical School, published in Frontiers in Immunology, has identified a mechanism by which these vaccines may contribute to sudden cardiac arrest, shedding light on a global surge in such events since the vaccines' introduction in early 2021. I will discuss the study's findings, the biological mechanisms involved, and the broader implications for public health. A few technical things will be said, but this is an important issue, worth the effort, especially those who are COVID mRNA vaxxed.
The core of the issue lies in how mRNA vaccines interact with human cells, particularly cardiomyocytes (heart muscle cells). The vaccines encode the SARS-CoV-2 spike protein, which is produced as a monomer in cells and then cleaved by the enzyme furin into two subunits: S1 and S2. The S1 subunit is secreted to stimulate an immune response, while the S2 subunit remains within the cell. Schreckenberg's team found that both Pfizer and Moderna vaccines produce two distinct spike protein monomers, which, within hours of vaccination, begin to aggregate into large, sticky molecular clusters. These clusters are particularly problematic in cardiomyocytes, where they trigger a cascade of harmful effects: oxidative stress, inhibited cell growth, and inflammation, all hallmarks of myocarditis, a condition involving heart muscle inflammation that can lead to fatal arrhythmias and sudden cardiac arrest.
The study's experiments involved transfecting human cell lines, AC16 cardiomyocytes, HEK-293, and HeLa cells, with mRNA from Pfizer and Moderna vaccines to track spike protein behavior. While all cell types produced spike protein monomers and their subunits, the aggregation patterns were consistent and particularly pronounced in heart cells. Notably, the S1 subunit was secreted into the surrounding environment, acting as an immunogen, but the sticky aggregates, including S2 subunits, remained trapped within cardiomyocytes. This retention of protein complexes in heart cells raises concerns about long-term damage, as these aggregates disrupt normal cellular function and promote inflammation, potentially setting the stage for severe cardiac events.
Myocarditis, though considered a rare adverse event following mRNA vaccination, has been increasingly reported, particularly among younger populations. The Schreckenberg study suggests that the aggregation of spike proteins in heart cells is a key driver of this condition. The inflammatory response triggered by these aggregates can weaken heart muscle, disrupt electrical signalling, and precipitate life-threatening arrhythmias. Unlike other cell types, where the S1 subunit is released, the entrapment of aggregates in cardiomyocytes means the heart bears the brunt of this inflammatory stress. This may explain the surge in sudden cardiac arrests observed globally since 2021, as the heart's delicate balance is disrupted without warning.
The study's findings align with broader concerns about mRNA vaccine safety. Various reports have highlighted growing evidence of cardiotoxic effects, with some studies suggesting that mRNA and spike protein accumulation in the heart can cause irreversible scarring, increasing the risk of sudden death months or even years after vaccination. These concerns are compounded by the fact that the long-term effects of retained spike protein aggregates are not fully understood, and the rapid development and deployment of mRNA vaccines left little time for comprehensive safety studies.
The discovery of spike protein aggregation as a mechanism for cardiac harm underscores the need for greater scrutiny of mRNA vaccine technology. Their potential to cause serious side effects, particularly in the heart, cannot be ignored. The Schreckenberg study calls for further investigation into the fate of spike proteins in the body and their long-term impact, especially in vulnerable populations. It also raises questions about whether the full spectrum of adverse effects was adequately explored before the vaccines were rolled out to billions worldwide. Spoiler: they were not.
We critics of the vaccine rollout argue that public health authorities and pharmaceutical companies have downplayed these risks, choosing rapid deployment over thorough safety assessments. The study's findings fuel calls for independent research, improved monitoring of vaccine-related adverse events, and greater transparency in communicating risks to the public. The Schreckenberg study provides compelling evidence that mRNA vaccines, through the aggregation of spike proteins in heart cells, may contribute to a surge in sudden cardiac arrests by triggering inflammation and myocarditis. This mechanism, rooted in the complex behaviour of spike protein monomers and their subunits, highlights a critical gap in our understanding of mRNA vaccine safety. The potential of the mRNA vaccines to cause cardiac harm demands urgent attention. This seems to be coming in the US through HHS Robert Kennedy Jr.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1635478/abstract
"A groundbreaking new study has identified the mechanism used by Covid mRNA "vaccines" to trigger a sudden cardiac arrest in people who have received the injections.
A group of leading scientists in Germany found that the spike protein from the mRNA shots enters the cells and forms "clusters."
These clusters, when they form in the heart cells, cause inflammation, which triggers a deadly cardiac arrest without warning.
The findings of the study appear to have identified the root cause of the global sudden cardiac arrest surge that has been raging since the "vaccines were first rolled out for public use in early 2021.
The bombshell study was conducted by Dr. Rolf Schreckenberg and his team from Justus-Liebig University Gießen and Hannover Medical School.
Their findings were published in the medical journal Frontiers in Immunology.
Dr. Schreckenberg and his team uncovered startling evidence connecting mRNA vaccines to several cardiac side effects, including myocarditis.
Their research reveals that spike proteins, generated by both the Pfizer and Moderna COVID-19 vaccines, are not only a major contributor to immune responses but also play a central role in the inflammatory events leading to heart damage.
The study meticulously examined the behavior of spike proteins in human heart cells (cardiomyocytes) by transfecting them with the mRNA from the mRNA injections from Pfizer and Moderna.
This allowed the researchers to track the translation, cleavage, and aggregation of spike protein monomers inside human cells, as well as the formation of molecular clusters that have been linked to cellular stress and inflammation.
By utilizing advanced techniques to analyze how the spike proteins behave in various human cell lines, including HEK-293 and HeLa cells, the researchers were able to observe the distinct pattern of aggregation that occurred in heart cells specifically.
The researchers were able to identify the spike proteins' aggregation as playing a direct role in causing heart damage.
The research found that both Pfizer and Moderna's vaccines triggered the production of two types of spike protein monomers.
The spike protein monomers are the very components meant to provoke an immune response.
As the monomers entered the cells, they were cleaved by an enzyme called furin, creating the S1 subunit, which is central to immune activation.
The study revealed something more disturbing.
The team discovered that, within hours of "vaccination," these spike proteins began to aggregate into large, sticky clusters, particularly in human heart cells."