It is very interesting that now that Covid king, Dr Fauci, has moved on and is doing motivational talks for a hefty fee. It is what the retiring elites all do to keep bringing in the bacon, or is it smoked salmon and caviar? But, what is even more ironic, is now that Fauci is out to greener pastures, he has said in a peer-reviewed article, that the Covid vaxxes are “sub-optimal.” Something either works, or it does not, and if the vax is sub-optimal, then contrary to all that Fauci has said before, the vax does not work, and do not prevent Covid. Yet, the Australian government is now authorising fourth and even fifth jabs for the helpless population. Go figure.
https://igorchudov.substack.com/p/dr-fauci-knew-covid-vaccines-would
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00572-8
“What is remarkable about that study is the derogatory language Fauci et al. employ towards influenza and Covid vaccines.
Until the emergence of COVID-19, influenza had for many decades been the deadliest vaccine-preventable viral respiratory disease, one for which only less than suboptimal vaccines are available.
Less than suboptimal vaccines is a term that leaves little to the imagination. Suboptimal means “not good.” Less than suboptimal means “useless at best.”
The article presumably discusses “next-generation vaccines.” However, the next-generation talk is empty and speculative, without specific mentions of any new technology that Dr. Fauci and his coauthors can recommend. The substance of the Cell article only explains why current influenza vaccines cannot prevent influenza and why Covid vaccines cannot prevent Covid.
Although current influenza vaccines reduce the risk of severe disease, hospitalization, and death to some degree, their effectiveness against clinically apparent infection is decidedly suboptimal, ranging from 14% to 60% over the past 15 influenza seasons.1 Furthermore, the duration of vaccine-elicited immunity is measured only in months. Current vaccines require annual re-vaccination with updated formulations that are frequently not precisely matched to circulating virus strains.8 Although annual influenza vaccinations are strongly recommended for most of the general public and especially for persons in high-risk groups, including the elderly, those with chronic diseases, and pregnant women, vaccine acceptance by the general public is not ideal.9
As of 2022, after more than 60 years of experience with influenza vaccines, very little improvement in vaccine prevention of infection has been noted.
After retiring, Fauci does not mince words on Covid vaccines either:
During the COVID-19 pandemic, the rapid development and deployment of SARS-CoV-2 vaccines has saved innumerable lives and helped to achieve early partial pandemic control.
However, as variant SARS-CoV-2 strains have emerged, deficiencies in these vaccines reminiscent of influenza vaccines have become apparent. The vaccines for these two very different viruses have common characteristics: they elicit incomplete and short-lived protection against evolving virus variants that escape population immunity.
Fauci Knew Why Covid Vaccine Could Never Work
Fauci and his co-authors explain why Covid vaccine had no chance of working.
First, he asks a question that many vaccine skeptics brought up many times before:
This observation raises a question of fundamental importance: if natural mucosal respiratory virus infections do not elicit complete and long-term protective immunity against reinfection, how can we expect vaccines, especially systemically administered non-replicating vaccines, to do so?
Then Tony goes on to explain why the respiratory nature of Sars-Cov-2 does not lead to even a possibility of encountering a bloodborne immune response.
In stark contrast, the non-systemic respiratory viruses such as influenza viruses, SARS-CoV-2, and RSV tend to have significantly shorter incubation periods (Table 1) and rapid courses of viral replication. They replicate predominantly in local mucosal tissue, without causing viremia, and do not significantly encounter the systemic immune system or the full force of adaptive immune responses, which take at least 5–7 days to mature, usually well after the peak of viral replication and onward transmission to others. SARS-CoV-2 “RNAemia” (circulation of viral RNA in the bloodstream, as is seen with most mucosal respiratory virus infections, as distinct from viremia, in which infectious viruses can be cultured from the blood), has been reported, and RT-PCR levels of viral RNA have been linked to severe disease,23,24 similar to studies of influenza RNAemia.25,26 As a result, the non-systemically replicating respiratory viruses, apparently including SARS-CoV-2,13,14,15 tend to repeatedly re-infect people over their lifetimes without ever eliciting complete and durable protection.27
Regrettably, many of my unvaccinated readers report repeat infections with Covid-19. Even though I have had only one Covid so far, in Nov 2020, I am very cognizant that my natural immunity is far from perfect.
Another important factor to consider is that although RNA viruses share a similar inherent RNA-dependent RNA polymerase error rate,28 different viruses (and different open reading frames within their genomes) differ in their tolerance for mutation. Mutational constraints can be related to frequent overlapping open reading frames28 or functional constraints on the acquisition of nonsynonymous mutations as is the case, for example, with measles virus.29 In contrast, the external influenza A virus hemagglutinin and neuraminidase proteins are comparatively plastic, and positively selected nonsynonymous mutations result in immunologically significant antigenic drift,30,31 by the acquisition of nonsynonymous mutations in antigenic epitopes, as well as by altering the N-linked glycosylation patterns.32 Rapid antigenic drift affects the control of annual influenza epidemics8 and complicates the effort to produce broadly protective, “universal” influenza vaccines. The SARS-CoV-2 spike protein has shown a similar plasticity, with the emergence of multiple variants with altered antigenicity33 that has complicated its control through current vaccination strategies.34
Great, right? Fauci and his “science” are still injecting the original Wuhan strain-encoding mRNA, well into the fifth calendar year of the pandemic, while being fully aware that mutations have rendered those injections to be “less than suboptimal.” (the bivalent booster contains equal doses of Ba.5 and Wuhan variant-encoding mRNA)
Fauci Again Shows Knowledge of Immune Tolerance
Dr. Fauci shows great familiarity with “immune tolerance,” a condition affecting recipients of multiple mRNA vaccines:
The terms “disease tolerance” and “immune tolerance” refer to the still-incompletely characterized but distinct category of mammalian immune defense mechanisms that allow hosts to “accept” infection and other antigenic stimuli to optimize survival (reviewed in Medzhitov et al. and Iwasaki et al.). Because humans inhale and ingest enormous quantities of exogenous proteins with every breath and mouthful, the respiratory and gastrointestinal immune compartments have evolved to deal with continual and massive antigenic assaults from the outside world. (Immune responses to viral infection of the gastrointestinal mucosa have recently been reviewed, and are not discussed here.) Inhaled and ingested proteins must be identified and either tolerated or attacked and eliminated.
This is not the first time we caught Fauci being aware of immune tolerance and yet continuing to push tolerance-inducing mRNA Covid vaccines:
Fauci then speculates on what can be done to make a “new generation of vaccines.” His and his coauthors’ talk is very lame and exposes them as quacks who want to try out anything without a theoretical basis.
Appreciate the lack of any sense this passage makes:
For example, during times of significant viral circulation within human populations, can better protection be achieved with repeat dosing, or by sequential mucosal and systemic vaccination? Is frequent re-boosting a viable vaccine option, e.g., via self-administered home nasal vaccines? Also to be considered are possible ancillary roles for prophylactic antivirals, including “programmable antivirals” targeting conserved structures, antibodies, including therapeutic IgA and innate immunity stimulators as adjuncts to imperfect vaccines. It remains to be seen if vaccination and prophylaxis can be effectively combined at the population level.
It is disheartening that, during a man-made pandemic still taking hundreds of lives daily and still playing a role in excess mortality, we are led by people officially pushing for vaccines that they know to be “less than sub-optimal.”
Fauci Knew Covid Vaccine Would Never Stop the Pandemic
Fauci explained in the study cited above why a vaccine-induced blood (humoral) response to Sars-Cov-2 would never stop respiratory infections. And yet, he lied to us for THREE YEARS about how vaccines would be the key to “getting out of the pandemic” and getting to herd immunity.
It is very regrettable that our health leaders, realizing that Covid vaccine could never possibly stop the Covid pandemic, preached to us that we could reach herd immunity.
As a result, we have a dumpster fire of a pandemic and excess mortality not even explainable by official Covid death counts.
Tony, meanwhile, is collecting hefty “speaking engagement” fees.”