Recent revelations about Pfizer's COVID-19 mRNA vaccine raise alarming questions about its safety, pointing to potential links between the vaccine's plasmid DNA components and serious adverse events. A September 2025 article by Jon Fleetwood on Substack, highlights that Pfizer's vaccine plasmid contains three human DNA fragments — α-globin (blood), AES/TLE5 (immune), and MT-RNR1 (neurological) — which align precisely with the primary categories of reported injuries: blood/cardiovascular, immune, and neurological. These plasmids, designed to integrate DNA into genomes, are present in the final vaccine product, suggesting a novel mechanism for harm that demands immediate scrutiny. My essay explores the implications of these findings, the historical context of vaccine safety oversights, and why Australia and the global community must act swiftly to investigate and address these risks to protect public health.
The Bombshell: DNA Fragments and Injury Clusters
Pfizer's vaccine manufacturing process uses plasmids, DNA molecules engineered to insert genetic sequences into genomes, to produce mRNA. Fleetwood's analysis reveals that these plasmids contain three human DNA regulatory sequences: α-globin, which governs blood and cardiovascular functions; AES/TLE5, which regulates immune pathways; and MT-RNR1, linked to neurological and mitochondrial functions. Critically, these plasmids are not fully removed during manufacturing and are present in the vaccine administered to millions. Independent safety reviews in 2022 and 2024, corroborated by Pfizer's own 5.3.6 safety report, show that adverse events cluster in the exact same categories: blood (e.g., clotting disorders), immune (e.g., autoimmune conditions), and neurological (e.g., seizures, cognitive issues).
The alignment is striking. The presence of integration-competent plasmids raises the possibility that these DNA fragments could insert into recipients' genomes, disrupting critical physiological systems. For example, α-globin integration could dysregulate blood vessel function, leading to clots or haemorrhages; AES/TLE5 could trigger immune overreactions, causing autoimmunity; and MT-RNR1 could impair mitochondrial function, contributing to neurological disorders. This hypothesis, while unconfirmed, is supported by the precise correlation between the plasmid's genetic components and the observed injury patterns, a connection Fleetwood claims was first identified in 2025. If true, it suggests Pfizer's vaccine design itself may be driving the harms, a possibility that warrants halting its use pending investigation.
Historical Context: Ignoring Vaccine Risks
This is not the first time vaccine safety concerns have been sidelined. As outlined in A Midwestern Doctor's work, the phenomenon of "disease provocation," where vaccines exacerbate the diseases they aim to prevent, has been documented for over a century. Historical examples include typhoid vaccines triggering outbreaks, tuberculosis therapies worsening infections, and polio vaccinations causing paralysis, often due to immune suppression or off-target effects like Original Antigenic Sin (OAS). Similarly, the HPV vaccine increased cervical cancer risk in women with pre-existing infections, a risk ignored to maximise sales. These cases reflect a pattern: inconvenient safety data are dismissed to protect the "safe and effective" narrative, often at the cost of public health.
Pfizer's own history raises red flags. A 2021 BMJ report exposed data integrity issues in its COVID-19 vaccine trials, with whistle-blower Brook Jackson alleging falsified data and inadequate adverse event follow-up by contractor Ventavia. More recently, a 2023 Ontario preprint confirmed the presence of SV40 promoter sequences in Pfizer's plasmid, a known enhancer of DNA integration, which was not fully disclosed to regulators. These revelations, combined with the 2025 Cleveland Clinic data showing increased COVID-19 susceptibility with more boosters, suggest a systemic failure to prioritise safety over profit. The refusal to test for pre-existing infections before vaccination, seen with both HPV and COVID-19, further mirrors historical oversights, amplifying risks like disease provocation.
Australia's Context: A Vulnerable Landscape
Australia's aggressive push for digital control, exemplified by the 2025 social media ban for under-16s and activist-driven censorship of video games, creates a chilling environment for discussing vaccine safety. The eSafety Commissioner's misleading claims about YouTube's dangers, debunked by Sky News, reflect a broader trend of suppressing dissent to enforce compliance. This "anarcho-tyranny," where core governance falters while speech and behaviour are tightly policed, parallels the medical establishment's dismissal of vaccine risks. Australia's strict defamation and hate speech laws, combined with proposed digital ID systems, could stifle whistle-blowers or researchers raising alarms about Pfizer's vaccine, as seen in Germany's criminalisation of X managers for resisting data demands.
The public health implications are significant. Australia's high vaccination rates, driven by mandates during the COVID-19 pandemic, mean millions received Pfizer's shot. If the plasmid DNA hypothesis is correct, a portion of the population could face long-term health risks from genomic integration, particularly in vulnerable groups like children or those with pre-existing conditions. The Kaiser poll showing only 49% of Americans trust the CDC or FDA on vaccine safety, reflects a growing distrust that Australia risks mirroring if it ignores these concerns. Open debate, protected by robust free speech laws, is essential to ensure transparency and accountability.
Scientific and Ethical Concerns
The presence of human DNA fragments in vaccines raises profound questions. Plasmids are designed for gene editing, and their integration into human genomes could lead to unpredictable outcomes, from chronic inflammation to oncogenesis, cancer. The SV40 promoter, identified in Pfizer's plasmid, is particularly concerning due to its historical link to cancer in polio vaccines. The lack of pre-vaccination testing for COVID-19 or other infections, as with HPV, increases the risk of immune suppression or disease provocation, as seen in cases where COVID-19 worsened post-vaccination.
Ethically, the failure to disclose these risks violates informed consent. Pfizer's 5.3.6 safety report, buried until FOIA requests surfaced, confirms the injury clusters, but was not widely publicised. The 2021 Ventavia scandal and the 2023 suppression of scientists raising safety concerns, as documented by Joshua Guetzkow, highlight a culture of opacity. Australia's reliance on global vaccine approvals, often led by the FDA and EMA, means it inherits these flaws, underscoring the need for independent scrutiny.
To address these concerns, Australia and the global community must act decisively:
1.Halt Pfizer's Vaccine: Suspend its use until independent studies confirm or refute the plasmid integration hypothesis, prioritising public safety over corporate interests.
2.Launch Investigations: Conduct transparent, non-government-led inquiries into Pfizer's safety data, focusing on DNA fragments and their correlation with adverse events.
3.Mandate Pre-Vaccination Testing: Require screening for pre-existing infections to prevent immune suppression or disease provocation, learning from HPV and COVID-19 oversights.
4.Enhance Transparency: Release all vaccine trial data, including plasmid sequences, and establish independent oversight bodies to review safety signals.
5.Protect Free Speech: Enact laws to safeguard whistle-blowers and researchers discussing vaccine risks, countering Australia's censorship trends to foster open debate.
Conclusion: A Reckoning for Vaccine Safety
Pfizer's vaccine, with its plasmid DNA fragments aligning with blood, immune, and neurological injuries, represents a potential public health crisis that demands immediate action. Historical parallels, typhoid, polio, and HPV, show what happens when safety concerns are ignored for profit or dogma. Australia, already grappling with eroded civil liberties, cannot afford to suppress discussion of these risks. By halting the vaccine, investigating its design, and protecting free speech, Australia can lead a global push for transparency and accountability. The stakes are clear: ignoring this bombshell risks repeating the mistakes of the past, undermining trust, and endangering lives.
https://jonfleetwood.substack.com/p/bombshell-pfizers-own-safety-data
Summary:
Pfizer's vaccine plasmid contains three human DNA fragments: α-globin (blood), AES/TLE5 (immune), MT-RNR1 (neurological).
Plasmids integrate—they're built to insert DNA into genomes—and these fragments are present in the final shot.
Independent reviews and Pfizer's own 5.3.6 safety report show the same triad of serious adverse events: blood, immune, neurological.
The alignment is exact: plasmid blueprint ↔ injury clusters.
Implication: these human DNA fragments may be integrating into patients' genomes and driving the injuries.
Bottom line: Grounds to pull the shot and launch an immediate government investigation.
What We Reported FirstOver the weekend, I revealed … that Pfizer's vaccine plasmid contains three human DNA regulatory sequences:
α-globin: regulates blood and cardiovascular functions.
AES/TLE5: regulates immune pathways.
MT-RNR1: linked to neurological and mitochondrial functions.
These are not inert add-ons.
By definition, plasmids are integration-competent DNA molecules—they are the very tools used in gene engineering to insert sequences into genomes.
These plasmids, used in Pfizer's COVID-19 mRNA shot manufacturing process, are present in the vaccine that ends up injected into people.
In that first article, I highlighted how independent safety reviews in 2022 and 2024 concluded that serious adverse events (AEs) after COVID vaccination concentrate in three categories: blood/cardiovascular, immune, and neurological.
What no one has pointed out until now is that the three human DNA fragments built into Pfizer's plasmid line up exactly with the three main categories of serious adverse events—raising the bombshell possibility that these very fragments are what's causing the injuries.
If true, this means Pfizer's plasmid design itself may be seeding the very categories of harm now showing up in patients—a novel connection no one has made until now, and one that could finally explain with precision why blood, immune, and neurological injuries dominate the safety signal.
That possibility alone is grounds to pull Pfizer's shot from the market immediately.
And it casts a dark shadow over any technology that uses plasmids carrying human gene sequences, since the risk of genome integration and system-level injury cannot be ruled out."