George Soros and the Global Elites May Live Forever Now! By Uncle Len, the Eternally Ageing

     There are a few details on the net about this at present, but Australia researchers claim to have developed cell reprogramming process that could in principle make a 70 year old have the same spring in his/her footsteps than a 20 year old. In other words, the fountain of youth:

     The above article is behind a paywall, of $ 28 for every four weeks, which I cannot afford. Hell, I live on about $ 28 every four weeks, so I can’t spend my meagre money on quality journalism, and I am not of quality anyway. Never mind, the fountain of eternal youth will not be for my kind, but will be monopolised by the elites like Soros, who will use it to eternally oppress us. We can be sure that any treatment will be massively expensive, way out of the pocket of the people who cannot even afford newspapers.

“An international team including UNSW researchers has made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars. In a paper published in Science today, the Harvard-led team identifies a critical step in the molecular process that allows cells to repair damaged DNA. Their experiments in mice suggest a treatment is possible for DNA damage from ageing and radiation. It is so promising it has attracted the attention of NASA, which believes the treatment can help its Mars mission. While our cells have an innate capability to repair DNA damage − which happens every time we go out into the sun, for example – their ability to do this declines as we age. The scientists identified that the metabolite NAD+, which is naturally present in every cell of our body, has a key role as a regulator in protein-to-protein interactions that control DNA repair. Treating mice with a NAD+ precursor, or “booster,” called NMN improved their cells’ ability to repair DNA damage caused by radiation exposure or old age.

“The cells of the old mice were indistinguishable from the young mice, after just one week of treatment,” said lead author Professor David Sinclair of UNSW School of Medical Sciences and Harvard Medical School Boston. Human trials of NMN therapy will begin within six months. “This is the closest we are to a safe and effective anti-ageing drug that’s perhaps only three to five years away from being on the market if the trials go well,” says Sinclair, who maintains a lab at UNSW in Sydney. ‘ And, here is the abstract from the Science article:

“DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD+ (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-protein interactions. The binding of NAD+ to the NHD domain of DBC1 (deleted in breast cancer 1) prevents it from inhibiting PARP1 [poly(adenosine diphosphate–ribose) polymerase], a critical DNA repair protein. As mice age and NAD+concentrations decline, DBC1 is increasingly bound to PARP1, causing DNA damage to accumulate, a process rapidly reversed by restoring the abundance of NAD+. Thus, NAD+directly regulates protein-protein interactions, the modulation of which may protect against cancer, radiation, and aging."

     Now I am the most scientifically illiterate person at this site, and this article should have been written by Brian Simpson, who teaches science, but it seems to me that this is all ore than a little way from turning a decaying circus clown like Uncle Len, back into a spring chicken. And, why would anyone bother?



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Monday, 19 April 2021
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